COVID, AMYLOID, AND INFLAMMATION
Literature collection of the CovAmInf workgroup.
Editors
Joshua T. Berryman
Abdul Mannan Baig
Artemi Bendandi
Daniel Bonhenry
Mattheos A.G. Koffas
Altered infective competence of the human gut microbiome in COVID-19 (2023)
Laura de Nies, Valentina Galata, Camille Martin-Gallausiaux, Milena Despotovic, Susheel Bhanu Busi, Chantal J. Snoeck, Lea Delacour, Deepthi Poornima Budagavi, Cédric Christian Laczny, Janine Habier, Paula-Cristina Lupu, Rashi Halder, Joëlle V. Fritz, Taina Marques, Estelle Sandt, Marc Paul O’Sullivan, Soumyabrata Ghosh, Venkata Satagopam, Geeta Acharya, Gloria Aguayo, Wim Ammerlaan, Ariane Assele-Kama, Christelle Bahlawane, Katy Beaumont, Nadia Beaupain, Lucrèce Beckers, Camille Bellora, Fay Betsou, Sandie Boly, Dirk Brenner, Eleftheria Charalambous, Emilie Charpentier, Manuel Counson, Brian De Witt, Olivia Domingues, Claire Dording, Bianca Dragomir, Tessy Fautsch, Jean-Yves Ferrand, Ana Festas Lopes, Joëlle Véronique Fritz, Manon Gantenbein, Laura Georges, Jérôme Graas, Gael Hamot, Anne-Marie Hanff, Maxime Hansen, Lisa Hefele, Estelle Henry, Margaux Henry, Eve Herkenne, Christiane Hilger, Judith Hübschen, Laetitia Huiart, Alexander Hundt, Gilles Iserentant, Stéphanie Kler, Pauline Lambert, Sabine Lehmann, Morgane Lemaire, Andrew Lumley, Monica Marchese, Sophie Mériaux, Maura Minelli, Alessandra Mousel, Maeva Munsch, Mareike Neumann, Magali Perquin, Achilleas Pexaras, Jean-Marc Plesseria, Lucie Remark, Bruno Santos, Aurélie Sausy, Margaux Schmitt, Sneeha Seal, Jean-Yves Servais, Florian Simon, Chantal Snoeck, Kate Sokolowska, Hermann Thien, Johanna Trouet, Jonathan Turner, Michel Vaillant, Daniela Valoura Esteves, Charlène Verschueren, Tania Zamboni, Pinar Alper, Piotr Gawron, Enrico Glaab, Clarissa Gomes, Borja Gomez Ramos, Vyron Gorgogietas, Valentin Groues, Wei Gu, Laurent Heirendt, Ahmed Hemedan, Sascha Herzinger, Anne Kaysen, Jacek Jaroslaw Lebioda, Tainà Marques, François Massart, Christiane Olesky, Venkata P. Satagopam, Claire Pauly, Laure Pauly, Lukas Pavelka, Guilherme Ramos Meyers, Armin Rauschenberger, Basile Rommes, Kirsten Rump, Reinhard Schneider, Valerie Schröder, Amna Skrozic, Lara Stute, Noua Toukourou, Christophe Trefois, Carlos Vega Moreno, Maharshi Vyas, Xinhui Wang, Anja Leist, Annika Lutz, Claus Vögele, Linda Hansen, João Manuel Loureiro, Beatrice Nicolai, Alexandra Schweicher, Femke Wauters, Tamir Abdelrahman, Estelle Coibion, Guillaume Fournier, Marie Leick, Friedrich Mühlschlegel, Marie France Pirard, Nguyen Trung, Philipp Jägi, Henry-Michel Cauchie, Delphine Collart, Leslie Ogorzaly, Christian Penny, Cécile Walczak, Rejko Krüger, Guy Fagherazzi, Markus Ollert, Feng Q. Hefeng, Patrick May, Paul Wilmes
PubMed: 36894986 DOI: 10.1186/s40168-023-01472-7
Post covid gut microbiomes were found to be enriched in pathogen-related genes, associated with rotavirus and beta-herpes virus amongst others. The key phrase in this paper is "infective competence": several gut microbiome species expressed genes associated with more agressive infective behaviour, and resistance to antimicrobials. It is not immediately clear how serious this, if we imagine harm from three categories as [(A) direct harm from the virus (B) harm by the host immune response (C) harm by altered "third-party" microbial entities] then the natural assumption is A>B>C, however a quantitative statement seems to still be missing.
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